N-bromobutanimide → 9-tert-butyl-2,14-dibromo-3-methoxy-5,6,10,11,12,13-hexahydroazocino[4',3':4,5]pyrrolo[2,1-a]isoquinolin-8(9H)-one

HRID 1971754ノート

反応式

HRID 1971754 の反応式
[C:1]([N:5]1[CH2:26][CH2:25][CH2:24][CH2:23][C:8]2[CH:9]=[C:10]3[C:19]4[CH:18]=[C:17]([Br:20])[C:16]([O:21][CH3:22])=[CH:15][C:14]=4[CH2:13][CH2:12][N:11]3[C:7]=2[C:6]1=[O:27])([CH3:4])([CH3:3])[CH3:2].C1C(=O)N([Br:35])C(=O)C1>CN(C=O)C.O>[C:1]([N:5]1[CH2:26][CH2:25][CH2:24][CH2:23][C:8]2[C:9]([Br:35])=[C:10]3[C:19]4[CH:18]=[C:17]([Br:20])[C:16]([O:21][CH3:22])=[CH:15][C:14]=4[CH2:13][CH2:12][N:11]3[C:7]=2[C:6]1=[O:27])([CH3:4])([CH3:2])[CH3:3]

参加物

5

反応物 2

HCID 67184N-bromobutanimideHCID 58124845HCID 58124845、化合物

生成物 1

HCID 581248589-tert-butyl-2,14-dibromo-3-methoxy-5,6,10,11,12,13-hexahydroazocino[4',3':4,5]pyrrolo[2,1-a]isoquinolin-8(9H)-one収率 90.7%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6228Dimethylformamide溶媒

実験手順

A solution of 506 mg of 19d in 4 ml of DMF was treated with 210 mg of NBS. The reaction was stirred for 45 min, then diluted with water, and stirred for an additional 15 min. The white precipitate was filtered and dried, to provide 543 mg of dibromide 25a.

後処理

  1. stirringstirred for an additional 15 min
  2. filtrationThe white precipitate was filtered
  3. customdried

出典と根拠

ORDレコード
ord-a97532ca43b04ecb813eb3a885bd9b5b
出典データセット
uspto-grants-2013_04
特許番号
US08431564B2

反応ノート

読み込み中…