Methanol → Methyl 3-phenylbutanoate
反応式
S(Cl)(Cl)=O.[C:5]1([CH:11]([CH3:16])[CH2:12][C:13]([OH:15])=[O:14])[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.[CH3:17]O>>[C:5]1([CH:11]([CH3:16])[CH2:12][C:13]([O:15][CH3:17])=[O:14])[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1参加物
4
実験手順
Thionyl chloride (44 ml, 91.4 mmol) is added dropwise to methanol (30 ml) at 0° C., followed by 3-phenylbutyric acid (10 g, 60.9 mmol). The reaction is stirred for 4 hours and the solvent is evaporated. The residue is partitioned between t-butylnethyl ether and aqueous ammonia. The organic phase is washed with water and brine, dried (Na2SO4) and evaporated to afford the title compound. MH+179.
後処理
- customthe solvent is evaporated
- customThe residue is partitioned between t-butylnethyl ether and aqueous ammonia
- washThe organic phase is washed with water and brine
- dry with materialdried (Na2SO4)
- customevaporated
出典と根拠
- ORDレコード
- ord-dabb0134a3664218ab80ff869d75d7fc
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07745462B2
反応ノート
読み込み中…