HCID 86657843、化合物 → tert-butyl 3-amino-4,4-difluoropiperidine-1-carboxylate

HRID 1972096ノート

反応式

HRID 1972096 の反応式
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][C:11]([F:15])([F:14])[CH:10]([N:16]=[N+]=[N-])[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]>CO.[Pd]>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][C:11]([F:14])([F:15])[CH:10]([NH2:16])[CH2:9]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

参加物

4

反応物 1

HCID 86657843HCID 86657843、化合物

生成物 1

HCID 67373260tert-butyl 3-amino-4,4-difluoropiperidine-1-carboxylate

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

To a solution of 3-azido-4,4-difluoro-piperidine-1-carboxylic acid tert-butyl ester (0.68 mmol, 0.18 g) in MeOH (4.0 mL), was added Pd—C (10% by wt, 30 mg) and stirred under H2 atmosphere (balloon) for 3 h. The catalyst was filtered and washed with DCM, and the filtrate was concentrated under reduced pressure to provide 3-amino-4,4-difluoro-piperidine-1-carboxylic acid tert-butyl ester.

後処理

  1. filtrationThe catalyst was filtered
  2. washwashed with DCM
  3. concentrationthe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-2e64d8a7cc864c8aa27baf6e4e60441b
出典データセット
uspto-grants-2013_04
特許番号
US08431575B2

反応ノート

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