2-Aminoindane → 2,3,4,7-tetrahydro-1H-inden-2-ylamine
反応式
[NH2:1][CH:2]1[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3]1.[Li]>N>[CH2:3]1[C:4]2[CH2:5][CH:6]=[CH:7][CH2:8][C:9]=2[CH2:10][CH:2]1[NH2:1]参加物
4
反応条件
- 温度
- -78 °C
実験手順
Liquid ammonia (80 ml) is condensed at −78° C. and 2-aminoindane (2 g, 15 mmol) is added, followed by lithium wire (2 g, 300 mmol) portionwise over 5 minutes. The reaction is stirred at −78° C. for 2 hours, then cautiously quenched with ethanol (100 ml) and warmed to ambient temperature overnight. Water is added, the mixture is extracted with ether and the combined organic extracts are washed with brine, dried (MgSO4) and evaporated to afford 2,3,4,7-tetrahydro-1H-inden-2-ylamine. [M+CH3CN] 177.
後処理
- customcondensed at −78° C.
- customcautiously quenched with ethanol (100 ml)
- temperaturewarmed to ambient temperature overnight
- additionWater is added
- extractionthe mixture is extracted with ether
- washthe combined organic extracts are washed with brine
- dry with materialdried (MgSO4)
- customevaporated
出典と根拠
- ORDレコード
- ord-620c63832b7e4dc5bc80e632159706c9
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07745462B2
反応ノート
読み込み中…