Diisopropylethylamine → 3-(3-Methoxybenzyl)-2,5-piperazinedione
反応式
FC(F)(F)C(O)=O.[NH2:8][CH2:9][C:10]([NH:12][C@H:13]([C:23]([O:25]CC)=O)[CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([O:21][CH3:22])[CH:16]=1)=[O:11].CCN(C(C)C)C(C)C>CO>[CH3:22][O:21][C:17]1[CH:16]=[C:15]([CH:20]=[CH:19][CH:18]=1)[CH2:14][CH:13]1[NH:12][C:10](=[O:11])[CH2:9][NH:8][C:23]1=[O:25]参加物
4
反応条件
- 温度
- 75 °C
実験手順
To a 100-mL round-bottomed flask was added ethyl glycyl-3-methoxyphenylalaninate trifluoroacetate (598 mg, 2.13 mmol), Hünig's base (0.371 mL, 2.13 mmol), and MeOH (20 mL). The reaction mixture was stirred at 75° C. for 24 h. The mixture was allowed to cool to room temperature. The solid formed was collected by filtration and washed with MeOH to give 3-(3-methoxybenzyl)-2,5-piperazinedione (423 mg).