Hydrochloric Acid → (5-Chloro-3-phenyl-1-benzofuran-2-yl)methanamine hydrochloride

HRID 1973043ノート

反応式

HRID 1973043 の反応式
[C:1]([C:3]1[O:4][C:5]2[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][C:6]=2[C:7]=1[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)#[N:2].B.Cl>O1CCCC1>[ClH:18].[NH2:2][CH2:1][C:3]1[O:4][C:5]2[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][C:6]=2[C:7]=1[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 6331BoraneHCID 227634675-Chloro-3-phenyl-1-benzofuran-2-carbonitrile

生成物 1

HCID 22763506(5-Chloro-3-phenyl-1-benzofuran-2-yl)methanamine hydrochloride

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

Treat 2.0 g. 2-cyano-5-chloro-3-phenylbenzofuran (0.008 mole) in 30 ml of tetrahydrofuran with 18 ml of borane in tetrahydrofuran (1 m solution). Reflux for 2 hours. Cool, add 10 ml of 10% hydrochloric acid and reflux for 1/2 hour. Evaporate the solution to dryness. Dissolve the residue in 50 ml of ethanol. Add 30 ml of ethanol saturated with hydrogen chloride. Dry the precipitate obtained to yield the title compound; m.p. 254°-256°.

後処理

  1. additionTreat 2.0 g
  2. temperatureReflux for 2 hours
  3. temperatureCool
  4. temperaturereflux for 1/2 hour
  5. customEvaporate the solution to dryness
  6. dissolutionDissolve the residue in 50 ml of ethanol
  7. additionAdd 30 ml of ethanol saturated with hydrogen chloride
  8. customDry the precipitate
  9. customobtained

出典と根拠

ORDレコード
ord-02cf2179bba7498a9e959b46be91ec3b
出典データセット
uspto-grants-1976_12
特許番号
US03996159

反応ノート

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