Hydroxyamine hydrochloride → (3aS,6aR)-2-butylhexahydrocyclopenta[c]pyrrol-5-one oxime
反応式
[CH2:1]([N:5]1[CH2:9][C@H:8]2[CH2:10][C:11](=O)[CH2:12][C@H:7]2[CH2:6]1)[CH2:2][CH2:3][CH3:4].Cl.[NH2:15][OH:16].C([O-])(=O)C.[Na+]>C(O)C.O>[CH2:1]([N:5]1[CH2:9][C@H:8]2[CH2:10][C:11](=[N:15][OH:16])[CH2:12][C@H:7]2[CH2:6]1)[CH2:2][CH2:3][CH3:4]参加物
6
実験手順
A suspension of (3aS,6aR)-2-butylhexahydrocyclopenta[c]pyrrol-5-one (0.467 g, 2.58 mmol), hydroxylamine hydrochloride (0.430 g, 6.19 mmol) and sodium acetate (0.842 g, 6.19 mmol) in ethanol (21 ml) and water (7 ml) is heated to reflux for 1 hour. The ethanol is evaporated and the residue partitioned between saturated aqueous NaHCO3 and EtOAc. The organic phase is washed with brine, dried (MgSO4) and evaporated to afford (3aS,6aR)-2-butylhexahydrocyclopenta[c]pyrrol-5-one oxime, MH+197.
後処理
- temperatureis heated
- temperatureto reflux for 1 hour
- customThe ethanol is evaporated
- customthe residue partitioned between saturated aqueous NaHCO3 and EtOAc
- washThe organic phase is washed with brine
- dry with materialdried (MgSO4)
- customevaporated
出典と根拠
- ORDレコード
- ord-b5a74cdf84d84e83bcf5cdc7da1404a2
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07745462B2
反応ノート
読み込み中…