Sodium Carbonate → HCID 21491289、化合物

HRID 1973380ノート

反応式

HRID 1973380 の反応式
[CH2:1]([N:3]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([F:13])[CH:11]=2)[N:6]=[C:5]([C:14]([O:16]CC)=[O:15])[C:4]1=[O:19])[CH3:2].C(=O)([O-])[O-].[Na+].[Na+]>CO.O>[CH2:1]([N:3]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([F:13])[CH:11]=2)[N:6]=[C:5]([C:14]([OH:16])=[O:15])[C:4]1=[O:19])[CH3:2]

参加物

5

反応物 2

HCID 10340Sodium CarbonateHCID 867342554-Ethyl-6-fluoro-3,4-dihydro-3-oxo-2-quinoxalinecarboxylic acid, ethyl ester

生成物 1

HCID 21491289HCID 21491289、化合物

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

実験手順

4-Ethyl-6-fluoro-3,4-dihydro-3-oxo-2-quinoxalinecarboxylic acid, ethyl ester (8 g) and sodium carbonate (0.25 g) in methanol (20 ml) and water (10 ml) were heated under reflux for 2 hours. The methanol was distilled off and the aqueous solution was acidified with hydrochloric acid and the solid was collected. It had m.p. 162.5°-164° (39%).

後処理

  1. temperatureunder reflux for 2 hours
  2. distillationThe methanol was distilled off
  3. customthe solid was collected

出典と根拠

ORDレコード
ord-3f662c70f4384580922093e7c61c580b
出典データセット
uspto-grants-1976_12
特許番号
US03997535

反応ノート

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