Sodium Hydroxide → (2E)-N-[3-(Trifluoromethyl)phenyl]-2H-quinolizin-2-imine
反応式
[Br-].[F:2][C:3]([F:22])([F:21])[C:4]1[CH:5]=[C:6]([CH:18]=[CH:19][CH:20]=1)[NH:7][C:8]1[CH:17]=[CH:16][N+:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[CH:9]=1.[OH-].[Na+]>O>[F:22][C:3]([F:2])([F:21])[C:4]1[CH:5]=[C:6]([N:7]=[C:8]2[CH:17]=[CH:16][N:15]3[C:10]([CH:11]=[CH:12][CH:13]=[CH:14]3)=[CH:9]2)[CH:18]=[CH:19][CH:20]=1参加物
4
実験手順
To a suspension of 2-(3-trifluoromethylanilino)quinolizinium bromide (22 g., 0.060 mole) in H2O (400 ml) was added a solution of NaOH (25 g., 0.62 mole) in H2O (250 ml). The mixture was stirred at about 50° for 1 hour, then chilled and filtered. The yellow product weighed 17 g (97%). The sample was boiled in benzene, filtered and diluted with hexane. Evaporation of the solvent gave yellow crystals which melted at 134°-135°.