Nitric Acid → Diethyl hydroxy(propan-2-yl)propanedioate

HRID 1973500ノート

反応式

HRID 1973500 の反応式
[N+]([O-])(O)=[O:2].[CH2:5]([O:7][C:8](=[O:18])[CH:9]([CH:15]([CH3:17])[CH3:16])[C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH3:6]>>[CH2:5]([O:7][C:8](=[O:18])[C:9]([CH:15]([CH3:16])[CH3:17])([C:10]([O:12][CH2:13][CH3:14])=[O:11])[OH:2])[CH3:6]

参加物

3

反応物 2

HCID 944Nitric AcidHCID 12966Diethyl isopropylmalonate

生成物 1

HCID 292277Diethyl hydroxy(propan-2-yl)propanedioate

実験手順

400 g (6.3 mols) of 98 % to 100 % nitric acid are placed in a sulphonating flask, and 10 g (0.05 mols) of isopropyl-malonic acid diethyl ester are added dropwise within 15 minutes at room temperature while stirring. The clear solution is allowed to stand at room temperature for 48 hours. Most of the nitric acid is then carefully removed by evaporation on a rotary evaporator under a water pump vacuum, the residue is distributed between an aqueous potassium hydrogen carbonate solution and a sufficient amount of methylene chloride and is worked up in the usual manner. The methylene chloride phases are again extracted with a small amount of water, dried over sodium sulphate, and the solvent is carefully removed by evaporation in a vacuum. The resulting crude product is distilled in a high vacuum and yields isopropyl-tartronic acid diethyl ester having a B.P. of 65°-67° (0.05 mm of Hg), nD20 = 1.4289.

後処理

  1. customMost of the nitric acid is then carefully removed by evaporation on a rotary evaporator under a water pump vacuum
  2. extractionThe methylene chloride phases are again extracted with a small amount of water
  3. dry with materialdried over sodium sulphate
  4. customthe solvent is carefully removed by evaporation in a vacuum
  5. distillationThe resulting crude product is distilled in a high vacuum

出典と根拠

ORDレコード
ord-e41e65256ec2447ba7c5cb5a90095e3e
出典データセット
uspto-grants-1976_12
特許番号
US03997593

反応ノート

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