Hydrochloric Acid → p-n-Hexylcinnamic acid

HRID 1973618

反応式

HRID 1973618 の反応式
[CH2:1]([C:7]1[CH:14]=[CH:13][C:10]([CH:11]=O)=[CH:9][CH:8]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6].C(O)(=O)[CH2:16][C:17]([OH:19])=[O:18].Cl>N1CCCCC1.N1C=CC=CC=1>[CH2:1]([C:7]1[CH:14]=[CH:13][C:10]([CH:11]=[CH:16][C:17]([OH:19])=[O:18])=[CH:9][CH:8]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6]

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 867Malonic AcidHCID 170813Benzaldehyde, 4-hexyl-

生成物 1

HCID 53878923p-n-Hexylcinnamic acid

試薬・触媒・溶媒 2

HCID 8082Piperidine触媒HCID 1049Pyridine溶媒

反応条件

温度
100 °C

実験手順

9.4 G. of p-n-hexylbenzaldehyde in 5 ml. of absolute pyridine are treated with 5.15 g. of malonic acid and 5 drops of piperidine. The mixture is then heated at 100° C. for 11 hours, subsequently poured on to cold aqueous hydrochloric acid and extracted with ether. The p-n-hexylcinnamic acid obtained after recrystallization of the crude product from hexane/ether has a melting point of 107°-109° C.

後処理

  1. extractionextracted with ether

出典と根拠

ORDレコード
ord-808f5a798aad47faa36586fda8b11198
出典データセット
uspto-grants-1976_12
特許番号
US03997536

関連ノート

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