Potassium thiocyanate → HCID 54155438、化合物

HRID 1973631ノート

反応式

HRID 1973631 の反応式
Cl[CH2:2][CH2:3][C:4]([N:6]1[CH2:10][CH2:9][CH2:8][CH2:7]1)=[O:5].[S-:11][C:12]#[N:13].[K+]>C(O)C>[S:11]([CH2:2][CH2:3][C:4]([N:6]1[CH2:10][CH2:9][CH2:8][CH2:7]1)=[O:5])[C:12]#[N:13]

参加物

4

反応物 2

HCID 516872Potassium thiocyanateHCID 32712663-Chloro-1-(pyrrolidin-1-yl)propan-1-one

生成物 1

HCID 54155438HCID 54155438、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

1-(β-Chloropropionyl) pyrrolidine (16 grams; 0.1 mol), potassium thiocyanate (18 grams; 0.2 mol) and ethanol (100 ml) are charged into a glass reaction flask equipped with a mechanical stirrer and reflux condenser. The reaction mixture is then heated at reflux for a period of about 6 hours. After this time the reaction mixture is cooled and filtered. The filtrate is stripped of solvent and the residue is extracted with benzene. The benzene extract is evaporated under reduced pressure to yield 1-(β-thiocyanopropionyl) pyrrolidine as a residue.

後処理

  1. customequipped with a mechanical stirrer
  2. temperaturereflux condenser
  3. temperatureThe reaction mixture is then heated
  4. temperatureat reflux for a period of about 6 hours
  5. temperatureAfter this time the reaction mixture is cooled
  6. filtrationfiltered
  7. extractionthe residue is extracted with benzene
  8. extractionThe benzene extract
  9. customis evaporated under reduced pressure

出典と根拠

ORDレコード
ord-7a66f3532b734bfc87c1ddce421c0ab0
出典データセット
uspto-grants-1976_12
特許番号
US03998808

反応ノート

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