Potassium thiocyanate → 1-(alpha-Thiocyanoacetyl) azetidine

HRID 1973635ノート

反応式

HRID 1973635 の反応式
Cl[CH2:2][C:3]([N:5]1[CH2:8][CH2:7][CH2:6]1)=[O:4].[S-:9][C:10]#[N:11].[K+]>C(O)C>[S:9]([CH2:2][C:3]([N:5]1[CH2:8][CH2:7][CH2:6]1)=[O:4])[C:10]#[N:11]

参加物

4

反応物 2

HCID 516872Potassium thiocyanateHCID 25431591-(Azetidin-1-yl)-2-chloroethan-1-one

生成物 1

HCID 536707741-(alpha-Thiocyanoacetyl) azetidine

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

1-(α-Chloroacetyl) azetidine (13 grams; 0.1 mol), potassium thiocyanate (18 grams; 0.18 mol) and ethanol (100 ml) are charged into a glass reaction flask equipped with stirrer and reflux condenser. The reaction mixture is then heated at reflux, with stirring, for a period of about 4 hours. After this time the reaction mixture is cooled and filtered. The filtrate is then stripped of ethanol leaving a residue. The residue is extracted twice with hot benzene and the two benzene extracts are combined. The benzene extract is then evaporated under reduced pressure to yield 1-(α-thiocyanoacetyl) azetidine as a residue.

後処理

  1. customequipped with stirrer
  2. temperaturereflux condenser
  3. temperatureThe reaction mixture is then heated
  4. temperatureat reflux
  5. temperatureAfter this time the reaction mixture is cooled
  6. filtrationfiltered
  7. extractionThe residue is extracted twice with hot benzene
  8. extractionThe benzene extract
  9. customis then evaporated under reduced pressure

出典と根拠

ORDレコード
ord-d16fa4394c0e450db58adfab8008724e
出典データセット
uspto-grants-1976_12
特許番号
US03998808

反応ノート

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