Benzaldehyde → HCID 86734277、化合物

HRID 1973677

反応式

HRID 1973677 の反応式
[C:1]([NH:5][CH2:6][C@H:7]([OH:10])CO)([CH3:4])([CH3:3])[CH3:2].[CH:11](=[O:18])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.[CH:19]1C=CC=CC=1>O>[C:1]([N:5]1[CH2:6][CH:7]([OH:10])[O:18][C@@:11]1([CH3:19])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)([CH3:2])([CH3:3])[CH3:4]

参加物

5

反応物 3

HCID 240BenzaldehydeHCID 241BenzeneHCID 2733671(S)-3-(tert-Butylamino)propane-1,2-diol

生成物 1

HCID 86734277HCID 86734277、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

22 g of (S)-1-tert.butylamino-2,3-dihydroxypropane, 20.7 g of benzaldehyde and 46 cc of benzene are heated at reflux in a water separator for 16 hours. The benzene and benzaldehyde are removed by distillation and the residue is distilled in a high vacuum. (S)-3-tert. butyl-5-hydroxy-methyl-2-phenyloxazolidine is obtained as yellowish oil (B.P. 110°-125° at 0.01 mm of Hg); [α]20546 = 17.8° (c = 1.99; chloroform).

後処理

  1. customThe benzene and benzaldehyde are removed by distillation
  2. distillationthe residue is distilled in a high vacuum

出典と根拠

ORDレコード
ord-87237c1e6f21415095e22b72680f230e
出典データセット
uspto-grants-1976_12
特許番号
US03998835

関連ノート

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