Water → 3alpha-Acetoxy-5alpha-pregnane-11,20-dione

HRID 1973740ノート

反応式

HRID 1973740 の反応式
[OH:1][C@@H:2]1[CH2:21][CH2:20][C@@:19]2([CH3:22])[C@@H:4]([CH2:5][CH2:6][C@@H:7]3[C@@H:18]2[C:17](=[O:23])[CH2:16][C@@:15]2([CH3:24])[C@H:8]3[CH2:9][CH2:10][C@@H:11]2[C:12](=[O:14])[CH3:13])[CH2:3]1.[C:25](OC(=O)C)(=[O:27])[CH3:26].O>N1C=CC=CC=1>[C:25]([O:1][C@@H:2]1[CH2:21][CH2:20][C@@:19]2([CH3:22])[C@@H:4]([CH2:5][CH2:6][C@@H:7]3[C@@H:18]2[C:17](=[O:23])[CH2:16][C@@:15]2([CH3:24])[C@H:8]3[CH2:9][CH2:10][C@@H:11]2[C:12](=[O:14])[CH3:13])[CH2:3]1)(=[O:27])[CH3:26]

参加物

5

反応物 3

HCID 962WaterHCID 7918Acetic AnhydrideHCID 104845Alphaxalone

生成物 1

HCID 118727973alpha-Acetoxy-5alpha-pregnane-11,20-dione

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

A solution of 3α-hydroxy-5α-pregnane-11,20-dione (1 g) in pyridine (ca 5 ml) was treated with acetic anhydride (2.5 ml) and allowed to stand overnight. The reaction mixture was poured into water and the solid collected by filtration and dried to give the title compound m.p. 150°-151°.

後処理

  1. filtrationthe solid collected by filtration
  2. customdried

出典と根拠

ORDレコード
ord-25e966eb05ea4922a5fa0331b4c1c324
出典データセット
uspto-grants-1976_12
特許番号
US03998829

反応ノート

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