Trifluoroacetic acid → cis-3-Amino-2-azidomethyl-4-oxoazetidine

HRID 1974184ノート

反応式

HRID 1974184 の反応式
[N:1]([CH2:4][C@H:5]1[C@@H:8]([NH:9]C(OC(C)(C)C)=O)[C:7](=[O:17])[NH:6]1)=[N+:2]=[N-:3].FC(F)(F)C(O)=O>C(Cl)Cl>[NH2:9][C@H:8]1[C:7](=[O:17])[NH:6][C@H:5]1[CH2:4][N:1]=[N+:2]=[N-:3]

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 86734331cis-2-Azidomethyl-3-t-butoxycarbonylamino-4-oxoazetidine

生成物 1

HCID 86734332cis-3-Amino-2-azidomethyl-4-oxoazetidine

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

cis-2-Azidomethyl-3-t-butoxycarbonylamino-4-oxoazetidine (ca. 1 g) is dissolved in 2 ml of methylene chloride and the solution is cooled to 0° and treated with 0.5 ml of trifluoroacetic acid for 30 minutes at 0°. The solution is washed with 5% aqueous sodium bicarbonate and extracted with dilute hydrochloric acid. The aqueous phase is neutralized and extracted with ethyl acetate. Evaporation of the solvent gives the title compound.

後処理

  1. temperaturethe solution is cooled to 0°
  2. washThe solution is washed with 5% aqueous sodium bicarbonate
  3. extractionextracted with dilute hydrochloric acid
  4. extractionextracted with ethyl acetate
  5. customEvaporation of the solvent

出典と根拠

ORDレコード
ord-eecd997b997e4601848a1256f0fb5a89
出典データセット
uspto-grants-1976_12
特許番号
US04000154

反応ノート

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