Sodium borohydride → cis-3-Azido-2-hydroxymethyl-4-oxoazetidine

HRID 1974186ノート

反応式

HRID 1974186 の反応式
[N:1]([C@H:4]1[C:7](=[O:8])[NH:6][C@H:5]1[C:9](OC)=[O:10])=[N+:2]=[N-:3].[BH4-].[Na+]>>[N:1]([C@H:4]1[C:7](=[O:8])[NH:6][C@H:5]1[CH2:9][OH:10])=[N+:2]=[N-:3]

参加物

3

反応物 2

HCID 4311764Sodium borohydrideHCID 13566680Methyl (2R,3R)-3-azido-4-oxoazetidine-2-carboxylate

生成物 1

HCID 86734333cis-3-Azido-2-hydroxymethyl-4-oxoazetidine

実験手順

Methyl cis-3-azido-4-oxoazetidine-2-carboxylate was reduced with sodium borohydride as described in Preparation 3 and the product was chromatographed on silica gel with ethyl acetate as eluant to give cis-3-azido-2-hydroxymethyl-4-oxoazetidine.

後処理

  1. customas described in Preparation 3
  2. customthe product was chromatographed on silica gel with ethyl acetate as eluant

出典と根拠

ORDレコード
ord-8400b16c156646f5ba1853ca1cf6be9d
出典データセット
uspto-grants-1976_12
特許番号
US04000154

反応ノート

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