Methylamine → HCID 19101480、化合物

HRID 1974431ノート

反応式

HRID 1974431 の反応式
[CH3:1][NH2:2].Cl[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][OH:13].[OH-].[Na+]>O>[CH3:1][NH:2][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][OH:13]

参加物

5

反応物 3

HCID 6329Methylamine2 回HCID 14798Sodium HydroxideHCID 30849741-Nonanol, 9-chloro-

生成物 1

HCID 19101480HCID 19101480、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
100 °C

実験手順

400 g a 40% aqueous solution of methylamine and 180 g of 9-chlorononanol were introduced into an autoclave equipped with a stirrer, a thermometer and a pressure pump and heated to 100° C. At the temperature, 93 g of a 48% aqueous solution of sodium hydroxide was forcedly introduced to the autoclave over 6 hours and the resulting mixture was aged for 1 hours. After cooling, the content was taken out from the autoclave and unreacted methylamine and water were removed therefrom under reduced pressure. Then, ethanol was added thereto and sodium chloride thus precipitated was filtered off. Ethanol was distilled off from the filtrate and the resulting solution was further subjected to distillation to give 125 g of 9-(N-methylamino)nonanol.

後処理

  1. customequipped with a stirrer
  2. temperatureAfter cooling
  3. customwere removed
  4. additionThen, ethanol was added
  5. customsodium chloride thus precipitated
  6. filtrationwas filtered off
  7. distillationEthanol was distilled off from the filtrate
  8. distillationthe resulting solution was further subjected to distillation

出典と根拠

ORDレコード
ord-426abac6664346d6b4fd864a7f287fac
出典データセット
uspto-grants-1994_02
特許番号
US05282983

反応ノート

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