Aniline → 2-anilinoacetophenone

HRID 1974433ノート

反応式

HRID 1974433 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Br[CH2:9][C:10]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=[O:11]>C(O)C>[NH:1]([CH2:9][C:10]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=[O:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 6115AnilineHCID 6259Phenacyl bromide

生成物 1

HCID 11326242-anilinoacetophenone収率 54%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒2 回

反応条件

温度
22 °C

実験手順

To a solution of 102.44 grams (1.1 mol) of aniline in 500 mL of absolute ethanol stirring at 22° C. was added 99.52 grams (0.5 mol) of 2-bromoacetophenone while maintaining a reaction temperature of 22° C. The reaction was stirred for 1.5 hours at 22° C. during which time a light yellow precipitate formed. The crude product mixture was diluted with 200 mL of ethanol and the precipitated product was collected on a Buchner funnel and washed with 3×200 mL of ethanol, 1×200 mL water, and again 1×200 mL ethanol. The crude product was dried to afford 56.9 grams (0.27 mol, 54% yield) of 2-anilinoacetophenone, m. p.=98°-101° C.

後処理

  1. customformed
  2. customthe precipitated product was collected on a Buchner funnel
  3. washwashed with 3×200 mL of ethanol, 1×200 mL water, and again 1×200 mL ethanol
  4. dry with materialThe crude product was dried

出典と根拠

ORDレコード
ord-912dc07a06b6409c893f7068dc620752
出典データセット
uspto-grants-1994_02
特許番号
US05283165

反応ノート

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