関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Ammonia | HCID 222 | — |
| 反応物 | Ibuprofen, (+-)- | HCID 3672 | — |
| 反応物 | Potassium Phosphate, Tribasic | HCID 62657 | — |
| 反応物 | 2-(4-Isobutylphenyl)propiononitrile | HCID 108374 | — |
| 生成物 | Dexibuprofen | HCID 39912 | — |
反応手順
One ml of the reaction solution containing 100 μmol of potassium phosphate buffer solution (pH 8.0), 4.77 μmol of 2-(4'-isobutylphenyl)propionitrile and 0.02 unit of nitrilase was thoroughly shaken at 32° C. to carry out the reaction. The amounts of 2-(4'-isobutylphenyl)-propionitrile, 2-(4'-isobutylphenyl)propionic acid and ammonia for each reaction time were determined. The results are shown in the Figure. The optical purity of the formed S-(+)-2-(4'-isobutylphenyl)propionic acid was 98% for 6 hours, 96% for 24 hours and 95% for 40 hours.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05283193 |
|---|
| 出典データセット | uspto-grants-1994_02 |
|---|
| ORD ID | ord-a910e50445e34748afab0963e9b6fb00 |
|---|
| 出典メモ | uspto-grants-1994_02 |
|---|
