Acetic acid, [(4-fluoro-2-nitrophenyl)amino]oxo-, ethyl ester → 7-fluoro-1-hydroxyquinoxaline-2,3-(1H,4H)-dione
反応式
[C:1]([NH:8][C:9]1[CH:14]=[CH:13][C:12]([F:15])=[CH:11][C:10]=1[N+:16]([O-:18])=O)([C:3](OCC)=[O:4])=[O:2]>[Pd].CN(C=O)C>[F:15][C:12]1[CH:11]=[C:10]2[C:9]([NH:8][C:1](=[O:2])[C:3](=[O:4])[N:16]2[OH:18])=[CH:14][CH:13]=1参加物
4
実験手順
To a mixture of 5.6 g of 2-ethoxalylamino-5-fluoronitrobenzene and 170 ml of DMF was added 0.3 g of 10% Pd-C, and hydrogenation reaction was carried out at ordinary temperature and pressure. The reaction mixture was then filtered and concentrated under reduced pressure. The resulting residue was recrystallized from ethanol to provide 3.68 g (85%) of 7-fluoro-1-hydroxyquinoxaline-2,3-(1H,4H)-dione
後処理
- additionwas added
- filtrationThe reaction mixture was then filtered
- concentrationconcentrated under reduced pressure
- customThe resulting residue was recrystallized from ethanol
出典と根拠
- ORDレコード
- ord-068db328e3d749cb93d3bc464b49f557
- 出典データセット
- uspto-grants-1994_02
- 特許番号
- US05283244
反応ノート
読み込み中…