Sodium Hydroxide → 4-(2-Methyl-1H-indol-3-yl)butanoic acid

HRID 1974560ノート

反応式

HRID 1974560 の反応式
[CH3:1][C:2]1[NH:3][C:4]2[C:9]([C:10]=1[CH2:11][CH2:12][CH2:13][C:14]([O:16]C)=[O:15])=[CH:8][CH:7]=[CH:6][CH:5]=2.[OH-].[Na+]>CO>[CH3:1][C:2]1[NH:3][C:4]2[C:9]([C:10]=1[CH2:11][CH2:12][CH2:13][C:14]([OH:16])=[O:15])=[CH:8][CH:7]=[CH:6][CH:5]=2

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 10609557Methyl 4-(2-methylindol-3-yl)butyrate

生成物 1

HCID 150472604-(2-Methyl-1H-indol-3-yl)butanoic acid収率 79.4%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
20 °C

実験手順

To a solution of methyl 4-(2-methylindol-3-yl)-butyrate (1.65 g) in methanol (50 ml) was added 1N aqueous sodium hydroxide (18 ml) at 20° C. and the mixture was stirred at 20° C. for 3 hours. After evaporation of the solvent, the residue was poured into a mixture of ethyl acetate and 1N hydrochloric acid. The organic layer was separated, washed with water and brine, and dried over magnesium sulfate. After evaporation of solvent, the crystalline residue was washed with hexane to give 4(2-methylindol-3-yl)butyric acid (1.23 g) as reddish brown crystals.

後処理

  1. customAfter evaporation of the solvent
  2. additionthe residue was poured into a mixture of ethyl acetate and 1N hydrochloric acid
  3. customThe organic layer was separated
  4. washwashed with water and brine
  5. dry with materialdried over magnesium sulfate
  6. customAfter evaporation of solvent
  7. washthe crystalline residue was washed with hexane

出典と根拠

ORDレコード
ord-01a2cf39deea47b2a9d5f4fa99c3a8cf
出典データセット
uspto-grants-1994_02
特許番号
US05283251

反応ノート

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