Hydrogen Bromide → 1-[2-(4-Fluorophenylthio)-6-fluorophenyl]3-bromoprop-1-ene

HRID 1974759ノート

反応式

HRID 1974759 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([F:15])[C:10]=2[CH:16](O)[CH:17]=[CH2:18])=[CH:4][CH:3]=1.C(OCC)C.[BrH:25].O>CCCCCC>[F:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([F:15])[C:10]=2[CH:16]=[CH:17][CH2:18][Br:25])=[CH:4][CH:3]=1

参加物

6

反応物 4

HCID 260Hydrogen BromideHCID 962WaterHCID 3283Diethyl EtherHCID 191022051-(2-(4-Fluorophenylthio)-6-fluorophenyl)prop-2-en-1-ol

生成物 1

HCID 540068731-[2-(4-Fluorophenylthio)-6-fluorophenyl]3-bromoprop-1-ene

試薬・触媒・溶媒 1

HCID 8058Hexane溶媒

実験手順

1-(2-(4-fluorophenylthio)-6-fluorophenyl)prop-2-en-1-ol (2.29 g, 8.23 mmol) is dissolved in 10 ml of hexane and 10 ml of diethyl ether and cooled in an ice bath. Concentrated HBr acid (4.6 ml, 41.2 mmol) is then added dropwise and the reaction mixture is stirred vigorously for 5 hours at room temperature. The reaction mixture is then poured into water and extracted twice with diethyl ether. The extracts are washed with water and then brine and dried over MgSO4 to afford the subtitle compound.

後処理

  1. extractionextracted twice with diethyl ether
  2. washThe extracts are washed with water
  3. dry with materialbrine and dried over MgSO4

出典と根拠

ORDレコード
ord-51a5f4a8e8dc4914ada856c72ccb657d
出典データセット
uspto-grants-1994_02
特許番号
US05283361

反応ノート

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