Hydrochloric Acid → HCID 53978363、化合物

HRID 1974797ノート

反応式

HRID 1974797 の反応式
[C:1]([NH:14][CH2:15][CH2:16][C:17]([OH:19])=O)(=[O:13])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12].S(Cl)([Cl:22])=O.S(=O)=O.Cl>C(Cl)Cl>[C:1]([NH:14][CH2:15][CH2:16][C:17]([Cl:22])=[O:19])(=[O:13])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 1119Sulfur DioxideHCID 24386Thionyl ChlorideHCID 3262167Lauroyl beta-alanine

生成物 1

HCID 53978363HCID 53978363、化合物収率 101%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

反応条件

温度
20 °C

実験手順

46.8 g of N-lauroyl-β-alanine was dispersed in 155 ml of methylene chloride. Then, 24.8 g of thionyl chloride was added thereto within 10 minutes under stirring while maintaining the temperature of the mixture at 20° C. After the completion of the addition, the mixture was stirred at the same temperature for 30 minutes so as to complete the reaction. When the reaction solution thus obtained was analyzed by infrared spectroscopy, a peak at 1695 cm-1 due to carboxylic acid (--COOH) disappeared while a new peak due to acid chloride (--COCl) was formed at 1782 cm-1. These facts indicated that an acid chloride was obtained. Then, the methylene chloride employed as the solvent and side products (sulfur dioxide and hydrogen chloride) were distilled off from the reaction mixture under reduced pressure. Thus, 50.5 g of N-lauroyl-3-aminopropionic acid chloride was obtained.

後処理

  1. additionAfter the completion of the addition
  2. stirringthe mixture was stirred at the same temperature for 30 minutes so as
  3. customthe reaction
  4. customWhen the reaction solution thus obtained
  5. customwas formed at 1782 cm-1
  6. customwas obtained
  7. distillationwere distilled off from the reaction mixture under reduced pressure

出典と根拠

ORDレコード
ord-9a7a9e8a9afd4a8f95c3143fa88bde8a
出典データセット
uspto-grants-1994_02
特許番号
US05284602

反応ノート

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