4-(Methylamino)benzoic acid → 1-(4-Methylaminobenzoyl)-4-[2-(4-methylmercaptophenyl)ethyl]piperazine
反応式
[CH3:1][NH:2][C:3]1[CH:11]=[CH:10][C:6]([C:7]([OH:9])=O)=[CH:5][CH:4]=1.C1N=CN(C(N2C=NC=C2)=O)C=1.[CH3:24][S:25][C:26]1[CH:31]=[CH:30][C:29]([CH2:32][CH2:33][N:34]2[CH2:39][CH2:38][NH:37][CH2:36][CH2:35]2)=[CH:28][CH:27]=1>CN(C)C=O>[CH3:1][NH:2][C:3]1[CH:4]=[CH:5][C:6]([C:7]([N:37]2[CH2:36][CH2:35][N:34]([CH2:33][CH2:32][C:29]3[CH:30]=[CH:31][C:26]([S:25][CH3:24])=[CH:27][CH:28]=3)[CH2:39][CH2:38]2)=[O:9])=[CH:10][CH:11]=1参加物
5
実験手順
The 1-(4-methylaminobenzoyl)-4-[2-(4-methylmercaptophenyl)ethyl]piperazine is prepared from 1.66 g of 4-methylaminobenzoic acid, 1.95 g of N,N-carbonyldiimidazole and 2.35 g of 1-[2-(4-methylmercaptophenyl)ethyl]piperazine in dimethylformamide at 85°. The base is purified via the hydrochloride (m.p. 185°, decomp.) and melts at 120°-121°.