4-(Methylamino)benzoic acid → 1-(4-Methylaminobenzoyl)-4-[2-(4-methylmercaptophenyl)ethyl]piperazine

HRID 1975351

反応式

HRID 1975351 の反応式
[CH3:1][NH:2][C:3]1[CH:11]=[CH:10][C:6]([C:7]([OH:9])=O)=[CH:5][CH:4]=1.C1N=CN(C(N2C=NC=C2)=O)C=1.[CH3:24][S:25][C:26]1[CH:31]=[CH:30][C:29]([CH2:32][CH2:33][N:34]2[CH2:39][CH2:38][NH:37][CH2:36][CH2:35]2)=[CH:28][CH:27]=1>CN(C)C=O>[CH3:1][NH:2][C:3]1[CH:4]=[CH:5][C:6]([C:7]([N:37]2[CH2:36][CH2:35][N:34]([CH2:33][CH2:32][C:29]3[CH:30]=[CH:31][C:26]([S:25][CH3:24])=[CH:27][CH:28]=3)[CH2:39][CH2:38]2)=[O:9])=[CH:10][CH:11]=1

参加物

5

反応物 3

HCID 663454-(Methylamino)benzoic acidHCID 682631,1'-CarbonyldiimidazoleHCID 538599451-{2-[4-(Methylsulfanyl)phenyl]ethyl}piperazine

生成物 1

HCID 541174811-(4-Methylaminobenzoyl)-4-[2-(4-methylmercaptophenyl)ethyl]piperazine

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

The 1-(4-methylaminobenzoyl)-4-[2-(4-methylmercaptophenyl)ethyl]piperazine is prepared from 1.66 g of 4-methylaminobenzoic acid, 1.95 g of N,N-carbonyldiimidazole and 2.35 g of 1-[2-(4-methylmercaptophenyl)ethyl]piperazine in dimethylformamide at 85°. The base is purified via the hydrochloride (m.p. 185°, decomp.) and melts at 120°-121°.

後処理

  1. customThe base is purified via the hydrochloride (m.p. 185°, decomp.) and melts at 120°-121°

出典と根拠

ORDレコード
ord-225fc4c915684fd68275fc99b7a4c063
出典データセット
uspto-grants-1994_02
特許番号
US05286728

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