反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=O)[CH2:9][C:10]2[CH:15]=[CH:14][C:13]([C:16]([F:19])([F:18])[F:17])=[CH:12][CH:11]=2)=[CH:4][CH:3]=1.O.[NH2:22][NH2:23]>C(O)C>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[N:22][NH2:23])[CH2:9][C:10]2[CH:15]=[CH:14][C:13]([C:16]([F:19])([F:18])[F:17])=[CH:12][CH:11]=2)=[CH:4][CH:3]=1参加物
4
実験手順
5.1 g (18.1 mmol) of 4'-fluoro-2-(4-trifluoromethylphenyl)acetophenone was dissolved in 100 ml of ethanol, and 8.8 ml (181 mmol) of hydrazine monohydrate was added thereto. The mixture was refluxed under heating for 2 hours. After completion of the reaction, ethanol was distilled off under reduced pressure, and water was added to the residue. The mixture was extracted with dichloromethane. The extract was dried over an hydrous sodium sulfate, and the solvent was distilled off to obtain [4'-fluoro-2-(4-trifluoromethylphenyl)acetophenone]hydrazone as a yellow oily substance.
後処理
- temperatureThe mixture was refluxed
- temperatureunder heating for 2 hours
- distillationwas distilled off under reduced pressure, and water
- additionwas added to the residue
- extractionThe mixture was extracted with dichloromethane
- dry with materialThe extract was dried over an hydrous sodium sulfate
- distillationthe solvent was distilled off
出典と根拠
- ORDレコード
- ord-5ddb47e1406345ea80569a0f87ba740d
- 出典データセット
- uspto-grants-1994_02
- 特許番号
- US05288727
関連ノート
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