Pyridine → (1S,4aS,7aR)-7-[2-(acetoxy)ethyl]-1-[1-(ethoxy)ethoxy]-1,4a,5,7a-tetrahydrocyclopenta[c]pyrane-4-carboxylic acid methylester

HRID 1976370ノート

反応式

HRID 1976370 の反応式
[CH3:1][O:2][C:3]([C:5]1[C@H:6]2[CH2:19][CH:18]=[C:17]([CH2:20][CH2:21][OH:22])[C@@H:7]2[C@H:8]([O:11][CH:12]([O:14][CH2:15][CH3:16])[CH3:13])[O:9][CH:10]=1)=[O:4].N1C=CC=CC=1.[C:29](OC(=O)C)(=[O:31])[CH3:30]>ClCCl.CN(C1C=CN=CC=1)C>[CH3:1][O:2][C:3]([C:5]1[C@H:6]2[CH2:19][CH:18]=[C:17]([CH2:20][CH2:21][O:22][C:29](=[O:31])[CH3:30])[C@@H:7]2[C@H:8]([O:11][CH:12]([O:14][CH2:15][CH3:16])[CH3:13])[O:9][CH:10]=1)=[O:4]

参加物

6

反応物 3

HCID 1049PyridineHCID 7918Acetic AnhydrideHCID 57042520(1S,4aS,7aR)-1-[1-(ethoxy)ethoxy]-7-[2-(hydroxy)ethyl]-1,4a,5,7a-tetrahydrocyclopenta[c]pyrane-4-carboxylic acid methylester

生成物 1

HCID 57302883(1S,4aS,7aR)-7-[2-(acetoxy)ethyl]-1-[1-(ethoxy)ethoxy]-1,4a,5,7a-tetrahydrocyclopenta[c]pyrane-4-carboxylic acid methylester収率 89%

試薬・触媒・溶媒 2

HCID 142844-(Dimethylamino)pyridine触媒HCID 6344Dichloromethane溶媒

実験手順

1.63 g of the above (1S,4aS,7aR)-1-[1-(ethoxy) ethoxy]-7-[2-(hydroxy) ethyl]-1,4a,5,7a-tetrahydrocyclopenta [c] pyrane-4-carboxylic acid methylester were dissolved in dichloromethane followed by addition of 1.7 ml of pyridine and DMAP. Next, 1.0 ml of acetic anhydride were added followed by stirring for 3 hours at room temperature. The reaction mixture was then extracted with ether. After washing the organic phase with 2N aqueous hydrochloric acid, saturated aqueous sodium bicarbonate and brine, it was dried over anhydrous magnesium sulfate. After distilling off the solvent under reduced pressure, the residue was purified by silica gel chromatography to obtain a colorless oil from the hexane-ether eluate in the form of (1S,4aS,7aR)-7-[2-(acetoxy) ethyl]-1-[1-(ethoxy) ethoxy]-1,4a,5,7a-tetrahydrocyclopenta [c] pyrane-4-carboxylic acid methylester (1.65 g, yield: 89%). The physicochemical properties of this compound are described below.

後処理

  1. extractionThe reaction mixture was then extracted with ether
  2. washAfter washing the organic phase with 2N aqueous hydrochloric acid, saturated aqueous sodium bicarbonate and brine, it
  3. dry with materialwas dried over anhydrous magnesium sulfate
  4. distillationAfter distilling off the solvent under reduced pressure
  5. customthe residue was purified by silica gel chromatography

出典と根拠

ORDレコード
ord-78e7d602ab494bae8b476284eefc6b41
出典データセット
uspto-grants-2001_05
特許番号
US06225478B1

反応ノート

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