Lithium Hydroxide → 2-[{[4-(2-Butynyloxy)phenyl]sulfonyl)(methyl)amino]-2-(4-chlorophenyl)acetic acid

HRID 1976450ノート

反応式

HRID 1976450 の反応式
[CH2:1]([O:5][C:6]1[CH:11]=[CH:10][C:9]([S:12]([N:15]([CH3:28])[CH:16]([C:21]2[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][CH:22]=2)[C:17]([O:19]C)=[O:18])(=[O:14])=[O:13])=[CH:8][CH:7]=1)[C:2]#[C:3][CH3:4].[OH-].[Li+]>>[CH2:1]([O:5][C:6]1[CH:7]=[CH:8][C:9]([S:12]([N:15]([CH3:28])[CH:16]([C:21]2[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][CH:22]=2)[C:17]([OH:19])=[O:18])(=[O:13])=[O:14])=[CH:10][CH:11]=1)[C:2]#[C:3][CH3:4]

参加物

3

反応物 2

HCID 3939Lithium HydroxideHCID 22645093Methyl 2-[{[4-(2-butynyloxy)phenyl]sulfonyl}(methyl)amino]-2-(4-chlorophenyl)acetate

生成物 1

HCID 226448912-[{[4-(2-Butynyloxy)phenyl]sulfonyl)(methyl)amino]-2-(4-chlorophenyl)acetic acid

実験手順

This ester was reacted with excess methanolic lithium hydroxide at room temperature, followed by evaporation of the methanol. The residue was dissolved in water and acidified with 2N hydrochloric acid to give 2-[{[4-(2-butynyloxy)phenyl]sulfonyl}(methyl)amino]-2-(4-chlorophenyl)acetic acid as colorless crystals, mp 170-172° C., Electrospray Mass Spec 406.4 (M−H)−

後処理

  1. customfollowed by evaporation of the methanol
  2. dissolutionThe residue was dissolved in water

出典と根拠

ORDレコード
ord-82ce77d398a643e3a1499223522d59f9
出典データセット
uspto-grants-2001_05
特許番号
US06225311B1

反応ノート

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