Sodium Hydroxide → 6-(methylsulfanyl)-1H-indole-2-carboxylic acid

HRID 1976732ノート

反応式

HRID 1976732 の反応式
C[O:2][C:3]([C:5]1[NH:6][C:7]2[C:12]([CH:13]=1)=[CH:11][CH:10]=[C:9]([S:14][CH3:15])[CH:8]=2)=[O:4].[OH-].[Na+]>>[CH3:15][S:14][C:9]1[CH:8]=[C:7]2[C:12]([CH:13]=[C:5]([C:3]([OH:4])=[O:2])[NH:6]2)=[CH:11][CH:10]=1

参加物

3

反応物 2

HCID 14798Sodium HydroxideHCID 4715405202584-20-1

生成物 1

HCID 39071736-(methylsulfanyl)-1H-indole-2-carboxylic acid収率 91%

実験手順

A mixture of methyl-6-methylsulfanyl-1H-indole-2-carboxylate (11.2 g, 51 mmol) and 2N NaOH (125 ml) was heated to reflux temperature for 30 minutes. The clear solution was cooled, and extracted with EtOAc. The aqueous fraction was acidified with concentrated HCl to pH=1, and the precipitate which formed, was filtered and dried to give 6-Methylsulfanyl-1H-indole-2-carboxylic acid (9.6 g, 91.0%).

後処理

  1. temperaturewas heated
  2. temperatureto reflux temperature for 30 minutes
  3. temperatureThe clear solution was cooled
  4. extractionextracted with EtOAc
  5. customthe precipitate which formed
  6. filtrationwas filtered
  7. customdried

出典と根拠

ORDレコード
ord-496beb0490f54e3eaf4c7848af5695b0
出典データセット
uspto-grants-2001_05
特許番号
US06228877B1

反応ノート

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