Hydrochloric Acid → 1-Methyl-2-oxo-1,2-dihydropyridine-4-carboxylic acid
反応式
[I-].[CH3:2][N+:3]1[CH:8]=[CH:7][C:6]([C:9]([O:11]C)=[O:10])=[CH:5][CH:4]=1.[OH-:13].[Na+].Cl>O>[CH3:2][N:3]1[CH:8]=[CH:7][C:6]([C:9]([OH:11])=[O:10])=[CH:5][C:4]1=[O:13]参加物
5
反応条件
- 温度
- 55 °C
実験手順
A solution of N-methyl-4-methoxycarbonylpyridinium iodide (2.00 g, 7.16 mmol) in water (10 mL) at room temperature was treated sequentially with 14M sodium hydroxide (1.0 mL) and 1.8M K3Fe(CN)6 (1.5 mL), stirred for 4 hours, treated again with 1.8M K3Fe(CN)6 once per hour for 4 hours, heated at 55° C. for one hour, cooled to room temperature, and treated with 6M HCl to pH 3. The precipitate was collected, washed with ether and dried under vacuum to provide 1.00 g of the desired product.
後処理
- temperaturecooled to room temperature
- customThe precipitate was collected
- washwashed with ether
- customdried under vacuum
出典と根拠
- ORDレコード
- ord-8c4da58f0dc249f5a86210fcb45b6efe
- 出典データセット
- uspto-grants-2001_05
- 特許番号
- US06228868B1
反応ノート
読み込み中…