Chlorosuccinimide → 1-(5-Bromo-7-chloro-2,3-dihydro-1H-indol-1-yl)ethan-1-one

HRID 1976785ノート

反応式

HRID 1976785 の反応式
[C:1]([N:4]1[C:12]2[C:7](=[CH:8][C:9]([Br:13])=[CH:10][CH:11]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2].[Cl:14]N1C(=O)CCC1=O>C(#N)C>[C:1]([N:4]1[C:12]2[C:7](=[CH:8][C:9]([Br:13])=[CH:10][C:11]=2[Cl:14])[CH2:6][CH2:5]1)(=[O:3])[CH3:2]

参加物

4

反応物 2

HCID 31398ChlorosuccinimideHCID 7218471-(5-bromo-2,3-dihydro-1H-indol-1-yl)ethan-1-one

生成物 1

HCID 186292691-(5-Bromo-7-chloro-2,3-dihydro-1H-indol-1-yl)ethan-1-one収率 39.9%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

A mixture of 1-acetyl-5-bromo-indoline (1.20 g, 5 mmol) and N-chlorosucinimide (0.734 g, 5.5 mmol) in acetonitrile (80 mL) was heated to reflux for 12 hours, cooled to room temperature, and concentrated. The concentrate was purified by flash column chromatography on silica gel to provide 0.548 g of the desired product.

後処理

  1. temperaturewas heated
  2. temperatureto reflux for 12 hours
  3. concentrationconcentrated
  4. customThe concentrate was purified by flash column chromatography on silica gel

出典と根拠

ORDレコード
ord-e5345672241a408481abc3290b234514
出典データセット
uspto-grants-2001_05
特許番号
US06228868B1

反応ノート

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