L-Phenylalanine → Phenylalanine sodium
反応式
[NH2:1][C@H:2]([C:10]([OH:12])=[O:11])[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[OH-].[Na+:14]>>[Na+:14].[NH2:1][C@H:2]([C:10]([O-:12])=[O:11])[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1参加物
3
実験手順
A solution of N-(2-chloro-6-methylbenzoyl)-4-[(2,6-dichlorophenyl)carbonyl]amino]-L-phenylalanine (0.15 g) in 1.0 N NaOH (0.3 mL) was applied to a 2×20 cm open column of C-18 reversed phase silica gel (40-63 μM, RP Silica Gel60, as supplied by EM Separations, Cat. 10167) eluting with water, then with 40-50% methanol in water to give N-(2-chloro-6-methylbenzoyl)-4-[(2,6-dichlorophenyl)carbonyl]amino]-L-phenylalanine sodium salt (147 mg) as an amorphous white solid after lyophilization.
後処理
- washeluting with water
出典と根拠
- ORDレコード
- ord-67b606452e124691a9cbece301ac3167
- 出典データセット
- uspto-grants-2001_05
- 特許番号
- US06229011B1
反応ノート
読み込み中…