化工社化工社 化学情報印刷レポート · 研究参考用
Water → 4-(1,1,2,2,2-Pentafluoroethyl)benzoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Potassium Hydroxide | HCID 14797 | — |
| 反応物 | 4-(Pentafluoroethyl)benzonitrile | HCID 14774185 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 4-(1,1,2,2,2-Pentafluoroethyl)benzoic acid | HCID 23067883 | 85% |
反応手順
A mixture of 4-pentafluoroethyl-benzonitrile (2.98 g, 13.5 mmol) and potassium hydroxide (3.03 g, 54.0 mmol) in water (40 mL) and ethanol (20 mL) was heated at reflux for 16 h. After cooling, the solution was partitioned between 1 M aq. hydrochloric acid solution and ethyl acetate. The organic layer was washed with brine, dried (MgSO4), and evaporated. Chromatography (SiO2, heptane-ethyl acetate gradient) produced the title compound (2.76 g, 85%). White solid, MS (ISP) 238.9 (M−H)−.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07745477B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-0130db70885d4824aae1fb9cc2481a2d |
| 出典メモ | uspto-grants-2010_06 |