反応式
[Cl:1][C:2]1[N:3]=[C:4]([CH3:19])[N:5]([CH2:8][CH2:9][CH2:10][CH2:11][N:12]2[CH2:17][CH2:16][C:15](=[O:18])[CH2:14][CH2:13]2)[C:6]=1[Cl:7].[Mg+2].[Cl-].[Cl-].[CH3:23][C:24]1[CH:29]=[CH:28][C:27]([Mg]Br)=[CH:26][CH:25]=1.[Cl-].[NH4+]>O1CCCC1>[Cl:1][C:2]1[N:3]=[C:4]([CH3:19])[N:5]([CH2:8][CH2:9][CH2:10][CH2:11][N:12]2[CH2:17][CH2:16][C:15]([OH:18])([C:27]3[CH:28]=[CH:29][C:24]([CH3:23])=[CH:25][CH:26]=3)[CH2:14][CH2:13]2)[C:6]=1[Cl:7]参加物
反応物 4
生成物 1
試薬・触媒・溶媒 1
実験手順
A solution of 1.0 g (3.3 mmol) of 4,5-dichloro-2-methyl-1-(4-(4-oxo-1-piperidyl)butyl]-1H-imidazole in 10 ml of anhydrous tetrahydrofuran is added to a suspension of 1.08 g (11.4 mmol) of MgCl2 in 15 ml of anhydrous THF at −40° C. and under a nitrogen atmosphere. The mixture is stirred for 5 minutes and then, at −40° C., 6.8 ml of a 1.0M solution of 4-methylphenylmagnesium bromide are added. The resulting suspension is stirred for 15 minutes at −40° C. and for 3 hours at room temperature. An aqueous ammonium chloride solution is then added and the tetrahydrofuran is evaporated. The resulting aqueous phase is extracted with chloroform. The chloroform phase is washed with water, dried with anhydrous sodium sulfate and evaporated to dryness, a crude product being obtained which is purified by chromatography on silica gel, giving 1.02 g (2.6 mmol) of 4,5-dichloro-1-{4-[4-hydroxy-4-(4-methylphenyl)-1-piperidyl]butyl}-2-methyl-1H-imidazole.
後処理
- stirringThe resulting suspension is stirred for 15 minutes at −40° C. and for 3 hours at room temperature
- customthe tetrahydrofuran is evaporated
- extractionThe resulting aqueous phase is extracted with chloroform
- washThe chloroform phase is washed with water
- dry with materialdried with anhydrous sodium sulfate
- customevaporated to dryness
- customa crude product being obtained which
- customis purified by chromatography on silica gel
出典と根拠
- ORDレコード
- ord-52679b0ced27406e9242f67f6cd57e32
- 出典データセット
- uspto-grants-2001_05
- 特許番号
- US06232329B1
関連ノート
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