Hydrochloric Acid → 5-(3,4-Dichlorobenzyl-carbamoyl)-thiophene-2-carboxylic acid
反応式
[OH-].[Na+].C([O:5][C:6]([C:8]1[S:9][C:10]([C:13](=[O:24])[NH:14][CH2:15][C:16]2[CH:21]=[CH:20][C:19]([Cl:22])=[C:18]([Cl:23])[CH:17]=2)=[CH:11][CH:12]=1)=[O:7])C.Cl>C(O)C>[Cl:23][C:18]1[CH:17]=[C:16]([CH:21]=[CH:20][C:19]=1[Cl:22])[CH2:15][NH:14][C:13]([C:10]1[S:9][C:8]([C:6]([OH:7])=[O:5])=[CH:12][CH:11]=1)=[O:24]参加物
5
実験手順
Aqueous 1M sodium hydroxide (16.3 mL; 16.3 mmole) was added to a stirring, solution of (12(a)) (1.17g; 3.3 mmole) in ethanol (70 mL). The reaction mixture was and adjusted to pH 2 by addition of 2M hydrochloric acid. The filtered solid was washed with water and dried in vacuo to give 5-(3,4-dichlorobenzyl-carbamoyl)-thiophene-2-carboxylic acid (12(b)) as a white solid (83%).