Acetanilide → N-(6-methyl-2-pyridyl)acetanilide

HRID 1977662ノート

反応式

[C:1]([NH:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)(=[O:3])[CH3:2].Cl[C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([CH3:18])[N:13]=1>>[CH3:18][C:14]1[N:13]=[C:12]([N:4]([C:1](=[O:3])[CH3:2])[C:5]2[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH:17]=[CH:16][CH:15]=1

参加物

反応物 2

HCID 904Acetanilide

HCID 876016-Chloro-2-picoline

生成物 1

HCID 21993566N-(6-methyl-2-pyridyl)acetanilide収率 7%

実験手順

Using acetanilide (9.16 g) and 2-chloro-6-methylpyridine (17.3 g), a reaction was made in the same manner as in 1) of Production Example 14. The subsequent purification by silica gel chromatography (developing solvent, ethyl acetate:hexane=1:1, ethyl acetate) produced N-(6-methyl-2-pyridyl)acetanilide (1.07 g; yield, 7%) as a pale brown oil.

後処理

customThe subsequent purification by silica gel chromatography (developing solvent, ethyl acetate:hexane=1:1, ethyl acetate)

出典と根拠

ORDレコード: ord-4bf9e1b3d0e24bc0b7a5e25de7e74f10
出典データセット: uspto-grants-2001_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06235730B1

反応ノート

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