Hydrogen Bromide → 1-(1-Bromo-2-methylpropyl)-4-chlorobenzene

HRID 1977719ノート

反応式

HRID 1977719 の反応式
[Cl:1][C:2]1[CH:12]=[CH:11][C:5]([CH:6](O)[CH:7]([CH3:9])[CH3:8])=[CH:4][CH:3]=1.[BrH:13]>>[Br:13][CH:6]([C:5]1[CH:11]=[CH:12][C:2]([Cl:1])=[CH:3][CH:4]=1)[CH:7]([CH3:9])[CH3:8]

参加物

3

反応物 2

HCID 260Hydrogen BromideHCID 202426Benzenemethanol, 4-chloro-alpha-(1-methylethyl)-

生成物 1

HCID 217034861-(1-Bromo-2-methylpropyl)-4-chlorobenzene

実験手順

A mixture of p-chloro-α-isopropylbenzyl alcohol (33.08 g) in 48% hydrobromic acid (330 mL) is stirred at room temperature for 1 hour and extracted with hexanes. The combined organic extracts are washed sequentially with water, saturated sodium hydrogen carbonate solution and water, dried over anhydrous sodium sulfate, and concentrated in vacuo to give the title product as a yellow oil (42.98 g) which is identified by NMR spectral analysis.

後処理

  1. extractionextracted with hexanes
  2. washThe combined organic extracts are washed sequentially with water, saturated sodium hydrogen carbonate solution and water
  3. dry with materialdried over anhydrous sodium sulfate
  4. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-ade00b8df7ff44f3a12cdf2e2885c98d
出典データセット
uspto-grants-2001_05
特許番号
US06235754B1

反応ノート

読み込み中…