Water → 2-(6-Methoxyindan-1-yl)ethanol

HRID 1977995

反応式

HRID 1977995 の反応式
[H-].[Al+3].[Li+].[H-].[H-].[H-].[CH3:7][O:8][C:9]1[CH:17]=[C:16]2[C:12]([CH2:13][CH2:14][CH:15]2[CH2:18][C:19](OCC)=[O:20])=[CH:11][CH:10]=1.O.S([O-])([O-])(=O)=O.[Mg+2]>C1COCC1.C(OCC)(=O)C>[OH:20][CH2:19][CH2:18][CH:15]1[C:16]2[C:12](=[CH:11][CH:10]=[C:9]([O:8][CH3:7])[CH:17]=2)[CH2:13][CH2:14]1

参加物

7

反応物 4

HCID 962WaterHCID 24083Sulfuric acid magnesium salt (1:1)HCID 11064342Ethyl (6-methoxyindan-1-yl)acetateHCID 21226445Aluminium lithium hydride

生成物 1

HCID 109978572-(6-Methoxyindan-1-yl)ethanol収率 93%

試薬・触媒・溶媒 2

HCID 8028Tetrahydrofuran溶媒2 回HCID 8857Ethyl Acetate溶媒

実験手順

To a suspension of lithium aluminum hydride (1.06 g, 27.9 mmol) in THF (150 ml) was added dropwise, under ice-cooling, a solution of ethyl (6-methoxyindan-1-yl)acetate (6.53 g, 27.9 mmol) in THF (20 ml), and the mixture was stirred for 15 minutes. To the reaction mixture was added water (1 ml), to which were further added ethyl acetate, anhydrous magnesium sulfate and celite. The mixture was subjected to filtration. The filtrate was concentrated under reduced pressure to give 4.96 g (yield 93%) of the above-titled compound as an oily product.

後処理

  1. additionwas added dropwise, under ice-
  2. temperaturecooling
  3. filtrationThe mixture was subjected to filtration
  4. concentrationThe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-5a1a1a3d392c47ab8d0f1ec52d0c4df1
出典データセット
uspto-grants-2001_05
特許番号
US06235789B1

関連ノート

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