Morpholine → HCID 69944285、化合物

HRID 1978090ノート

反応式

HRID 1978090 の反応式
N1CCOCC1.C([O:10][C:11]([C@H:13]([CH2:27][CH:28]([CH3:30])[CH3:29])[C@H:14]([O:19][CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[C:15]([O:17][CH3:18])=[O:16])=[O:12])C=C>O1CCCC1.C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[C:11]([C@H:13]([CH2:27][CH:28]([CH3:30])[CH3:29])[C@H:14]([O:19][CH2:20][C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1)[C:15]([O:17][CH3:18])=[O:16])([OH:12])=[O:10]

参加物

5

反応物 2

HCID 8083MorpholineHCID 69943797HCID 69943797、化合物

生成物 1

HCID 69944285HCID 69944285、化合物収率 121.2%

試薬・触媒・溶媒 2

HCID 178418397HCID 178418397、化合物触媒HCID 8028Tetrahydrofuran溶媒

実験手順

0.39 ml of morpholine and 0.05 g of tetrakis(triphenylphosphine)palladium(0) were added to a stirred solution of 0.15 g of methyl 3(R)-(allyloxycarbonyl)-2(S)-benzyloxy-5-methylhexanoate in 5 ml of tetrahydrofuran under a nitrogen atmosphere. After stirring the mixture for 0.5 hour the solvent was evaporated. The residue was dissolved in dichloromethane and washed in succession with 2M aqueous hydrochloric acid and water. The organic phase was dried over anhydrous magnesium sulphate and the solvent was evaporated. The residue was dissolved in diethyl ether and filtered. The diethyl ether solution was evaporated to give 0.16 g of methyl 3(R)-carboxy-2(S)-benzyloxy-5-methylhexanoate in the form of a yellow oil.

後処理

  1. customwas evaporated
  2. dissolutionThe residue was dissolved in dichloromethane
  3. washwashed in succession with 2M aqueous hydrochloric acid and water
  4. dry with materialThe organic phase was dried over anhydrous magnesium sulphate
  5. customthe solvent was evaporated
  6. dissolutionThe residue was dissolved in diethyl ether
  7. filtrationfiltered
  8. customThe diethyl ether solution was evaporated

出典と根拠

ORDレコード
ord-9a48ea7c47b84e3ebdb4d2dc61f24d4d
出典データセット
uspto-grants-2001_05
特許番号
US06235787B1

反応ノート

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