Sodium Iodide → 1-Bromo-2-(2-propoxyethoxy)benzene

HRID 1978723ノート

反応式

HRID 1978723 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[OH:8].C(=O)([O-])[O-].[K+].[K+].[I-].[Na+].Br[CH2:18][CH2:19][O:20][CH2:21][CH2:22][CH3:23]>CN(C=O)C.O>[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[O:8][CH2:18][CH2:19][O:20][CH2:21][CH2:22][CH3:23]

参加物

7

反応物 4

HCID 5238Sodium IodideHCID 72442-BromophenolHCID 11430Potassium CarbonateHCID 27341841-(2-Bromoethoxy)propane

生成物 1

HCID 219958661-Bromo-2-(2-propoxyethoxy)benzene

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6228Dimethylformamide溶媒

反応条件

温度
90 °C

実験手順

In DMF (120 ml) was dissolved 2-bromophenol (12 g), and to the solution were added potassium carbonate (14.4 g) and sodium iodide (10.4 g). To the mixture was added 2-bromoethylpropylether (10.4 ml), and the mixture was stirred at 90° C. for 16 hours. The reaction mixture was added to water, and the mixture was extracted with ethyl acetate, washed with saturated brine and dried with magnesium sulfate. Under reduced pressure, the solvent was evaporated, and the residue was purified with silica gel column chromatography (hexane/ethyl acetate=12/1) to give 1-bromo-2-(2-propoxyethoxy)benzene (14.4 g).

後処理

  1. extractionthe mixture was extracted with ethyl acetate
  2. washwashed with saturated brine
  3. dry with materialdried with magnesium sulfate
  4. customUnder reduced pressure, the solvent was evaporated
  5. customthe residue was purified with silica gel column chromatography (hexane/ethyl acetate=12/1)

出典と根拠

ORDレコード
ord-2389317e888a452fad20d5d8933e7411
出典データセット
uspto-grants-2001_05
特許番号
US06235771B1

反応ノート

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