Sodium Iodide → HCID 21995730、化合物

HRID 1978740

反応式

HRID 1978740 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[C:4]([O:9][CH2:10][CH3:11])[CH:3]=1.Br[CH2:13][CH2:14][CH3:15].[I-].[Na+].C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:13][CH2:14][CH3:15])=[C:4]([O:9][CH2:10][CH3:11])[CH:3]=1

参加物

6

反応物 4

HCID 5238Sodium IodideHCID 78401-BromopropaneHCID 11430Potassium CarbonateHCID 218775414-Bromo-2-ethoxyphenol

生成物 1

HCID 21995730HCID 21995730、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
75 °C

実験手順

A suspension of 4-bromo-2-ethoxyphenol (8 g), 1-bromopropane (4 ml), sodium iodide (5.5 g) and potassium carbonate (10.2 g) in DMF (10 ml) was stirred under nitrogen atmosphere at 75° C. overnight. The solvent was evaporated, and to the residue was added water. The mixture was extracted with ethyl acetate. The organic layer was washed with water and saturated brine and dried with anhydrous magnesium sulfate. The solvent was evaporated, and the residue was distilled under reduced pressure to give 1-bromo-3-ethoxy-4-propoxybenzene (8.5 g) as pale yellow oil.

後処理

  1. customThe solvent was evaporated
  2. additionto the residue was added water
  3. extractionThe mixture was extracted with ethyl acetate
  4. washThe organic layer was washed with water and saturated brine
  5. dry with materialdried with anhydrous magnesium sulfate
  6. customThe solvent was evaporated
  7. distillationthe residue was distilled under reduced pressure

出典と根拠

ORDレコード
ord-89e7e347ff354fe6a9f5d3a6785fac18
出典データセット
uspto-grants-2001_05
特許番号
US06235771B1

関連ノート

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