Sodium Hydroxide → 4-(5-Fluoro-2-methoxyphenyl)piperidine

HRID 1978832ノート

反応式

HRID 1978832 の反応式
C([N:3]1[CH2:8][CH2:7][CH:6]([C:9]2[CH:14]=[C:13]([F:15])[CH:12]=[CH:11][C:10]=2[O:16][CH3:17])[CH2:5][CH2:4]1)=O.[OH-].[Na+]>Cl.CO>[F:15][C:13]1[CH:12]=[CH:11][C:10]([O:16][CH3:17])=[C:9]([CH:6]2[CH2:7][CH2:8][NH:3][CH2:4][CH2:5]2)[CH:14]=1

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 15512821HCID 15512821、化合物2 回

生成物 1

HCID 155128224-(5-Fluoro-2-methoxyphenyl)piperidine

試薬・触媒・溶媒 2

HCID 313Hydrochloric Acid溶媒HCID 887Methanol溶媒

実験手順

The crude product of 1-formyl-4-(5-fluoro-2-methoxy-phenyl)-piperidine (0.80 g, 3.4 mmole) (Intermediate 3) was dissolved in HCl (16 mL, 0.5 N) and MeOH (5 mL), and the mixture was brought to reflux for 16 hours. The mixture was cooled to room temperature and basified with NaOH (2.5 N), and extracted with EtOAc (3×25 mL) to give 4-(5-fluoro-2-methoxy-phenyl)-piperidine which was used directly without further purification.

後処理

  1. temperatureto reflux for 16 hours
  2. extractionextracted with EtOAc (3×25 mL)

出典と根拠

ORDレコード
ord-3fbb02d2f0d8464dbf66c1607c6496b9
出典データセット
uspto-grants-2001_05
特許番号
US06239126B1

反応ノート

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