3-Pyridinecarboxylic acid, 4-(trifluoromethyl)- → Tert-butyl 3-amino-3-(4-trifluoromethyl-3-pyridinecarbonyloxyimino)propionate

HRID 1978981

反応式

HRID 1978981 の反応式
[F:1][C:2]([F:13])([F:12])[C:3]1[CH:8]=[CH:7][N:6]=[CH:5][C:4]=1[C:9]([OH:11])=[O:10].C(C1NC=CN=1)(C1NC=CN=1)=O.[C:26]([O:30][C:31]([CH2:33][C:34](=[N:36]O)[NH2:35])=[O:32])([CH3:29])([CH3:28])[CH3:27]>C1COCC1>[NH2:36][C:34](=[N:35][O:10][C:9]([C:4]1[CH:5]=[N:6][CH:7]=[CH:8][C:3]=1[C:2]([F:1])([F:12])[F:13])=[O:11])[CH2:33][C:31]([O:30][C:26]([CH3:28])([CH3:27])[CH3:29])=[O:32]

参加物

5

反応物 3

HCID 27775493-Pyridinecarboxylic acid, 4-(trifluoromethyl)-HCID 5250894Bis-(1H-imidazol-2-YL)-methanoneHCID 76589802tert-butyl 2-(N'-hydroxycarbamimidoyl)acetate

生成物 1

HCID 53931299Tert-butyl 3-amino-3-(4-trifluoromethyl-3-pyridinecarbonyloxyimino)propionate収率 51.6%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

30 g of 4-trifluoromethyl-3-pyridinecarboxylic acid is initially charged in 150 ml of dry THF and, a little at a time, admixed with 25.3 g of carbonyl-diimidazole. The mixture is stirred at room temperature for 30 min. 27.2 g of tert-butoxycarbonylacetamide oxime dissolved in 150 ml of THF are then added dropwise. The mixture is stirred overnight, the solvent is evaporated and the residue is taken up in ethyl acetate, washed three times with 1 M sulfuric acid and once with saturated sodium bicarbonate solution. Concentration of the ethyl acetate phase gives 28 g of the product as a pale yellow solid.

後処理

  1. additionare then added dropwise
  2. stirringThe mixture is stirred overnight
  3. customthe solvent is evaporated
  4. washwashed three times with 1 M sulfuric acid

出典と根拠

ORDレコード
ord-fdaa577ba9fd42aa8988ed42e6d7917c
出典データセット
uspto-grants-2001_05
特許番号
US06239160B1

関連ノート

読み込み中…