Hydrochloric Acid → 3-[[(4,6-Dimethylpyrimidin-2-yl)aminocarbonyl]amino sulfonyl]-2-thiophene carboxylic acid

HRID 1979497ノート

反応式

HRID 1979497 の反応式
[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]([NH:9][C:10]([NH:12][S:13]([C:16]2[CH:20]=[CH:19][S:18][C:17]=2[C:21]([O:23]C)=[O:22])(=[O:15])=[O:14])=[O:11])[N:3]=1.Cl>C(O)C.[OH-].[Na+].O>[CH3:8][C:6]1[CH:7]=[C:2]([CH3:1])[N:3]=[C:4]([NH:9][C:10]([NH:12][S:13]([C:16]2[CH:20]=[CH:19][S:18][C:17]=2[C:21]([OH:23])=[O:22])(=[O:15])=[O:14])=[O:11])[N:5]=1

参加物

6

反応物 2

HCID 313Hydrochloric AcidHCID 13390185Methyl 3-[[(4,6-dimethylpyrimidin-2-yl)aminocarbonyl]aminosulfonyl]-2-thiophenecarboxylate

生成物 1

HCID 137293093-[[(4,6-Dimethylpyrimidin-2-yl)aminocarbonyl]amino sulfonyl]-2-thiophene carboxylic acid

試薬・触媒・溶媒 3

HCID 702Ethanol溶媒HCID 962Water溶媒HCID 14798Sodium Hydroxide溶媒

実験手順

A solution of 1.0 g of methyl 3-[[(4,6-dimethylpyrimidin-2-yl)aminocarbonyl]aminosulfonyl]-2-thiophenecarboxylate in 10 ml of ethanol and 1 ml of 50% sodium hydroxide in water was stirred overnight at room temperature. To this was added icewater and aqueous hydrochloric acid until acidic, and the precipitate was filtered and washed first with acetone and then with methylene chloride. The product, 0.8 g, melted at 127°.

後処理

  1. filtrationwas filtered
  2. washwashed first with acetone

出典と根拠

ORDレコード
ord-fc7c9964dcba4ceeb1444144e7821047
出典データセット
uspto-grants-1984_11
特許番号
US04481029

反応ノート

読み込み中…