Pentafluoroaniline → 4-(Pentafluorophenyl)-1-carbethoxysemicarbazide
反応式
[F:1][C:2]1[C:7]([NH2:8])=[C:6]([F:9])[C:5]([F:10])=[C:4]([F:11])[C:3]=1[F:12].[C:13]([NH:18][NH:19][C:20](Cl)=[O:21])([O:15][CH2:16][CH3:17])=[O:14]>C1(C)C=CC=CC=1>[F:1][C:2]1[C:7]([NH:8][C:20](=[O:21])[NH:19][NH:18][C:13]([O:15][CH2:16][CH3:17])=[O:14])=[C:6]([F:9])[C:5]([F:10])=[C:4]([F:11])[C:3]=1[F:12]参加物
4
実験手順
Pentafluoroaniline (17 g, 0.106 mol) is dissolved in 300 ml of toluene with heating. The 2-carbethoxyhydrazinecarbonyl chloride, 19.4 g (0.122M) is added to the hot solution. The mixture is refluxed until a white solid precipitates. The solid is filtered to give 24.8 g. The product is crystallized by dissolving in ethyl acetate/toluene (1/2 by vol) and evaporating until crystals appear, mp 180°-182°.