Carbonyl fluoride → 4-Chloro-3-(trifluoromethyl)phenyl carbamic fluoride

HRID 1979629

反応式

HRID 1979629 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]=[C:9]=[O:10])=[CH:4][C:3]=1[C:11]([F:14])([F:13])[F:12].F.C(F)([F:18])=O>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([F:18])=[O:10])=[CH:4][C:3]=1[C:11]([F:12])([F:13])[F:14]

参加物

4

反応物 3

HCID 9623Carbonyl fluorideHCID 14917Hydrofluoric Acid2 回HCID 27332651-Chloro-4-isocyanato-2-(trifluoromethyl) benzene

生成物 1

HCID 204396094-Chloro-3-(trifluoromethyl)phenyl carbamic fluoride

反応条件

温度
24 °C

実験手順

4-Chloro-3-(trifluoromethyl)phenyl carbamic fluoride was prepared in situ by the reaction of 221 parts of 4-chloro-3-(trifluoromethyl)isocyanatobenzene and 450 parts of hydrogen fluoride added over a period of 15-20 minutes at about 4° C. The reaction mixture was then sealed in a polytetrafluoroethylene reactor, heated to about 24° C. and maintained thereat, with agitation, for about 96 hours. The reactor was then opened to atmospheric pressure and most of the hydrogen fluoride and carbonyl fluoride gases removed. Analysis of the remaining organic product by gas chromatographic techniques, using n-heptadecane as an internal standard indicated a yield of 77 parts of 4-chloro-3-(trifluoromethyl)benzenamine.

後処理

  1. additionadded over a period of 15-20 minutes at about 4° C
  2. customThe reaction mixture was then sealed in a polytetrafluoroethylene reactor
  3. temperaturemaintained
  4. customremoved

出典と根拠

ORDレコード
ord-f2907788c7834689b5bc788e03074260
出典データセット
uspto-grants-1984_11
特許番号
US04481370

関連ノート

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