Potassium Carbonate → N-Methyl-4-phenyl-4-piperidyl N-(8-trifluoromethyl-4-quinolyl)anthraniloyloxyacetate

HRID 1979728

反応式

HRID 1979728 の反応式
Cl.Cl[CH2:3][C:4]([O:6][C:7]1([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH2:12][CH2:11][N:10]([CH3:13])[CH2:9][CH2:8]1)=[O:5].[Na].[F:21][C:22]([F:44])([F:43])[C:23]1[CH:24]=[CH:25][CH:26]=[C:27]2[C:32]=1[N:31]=[CH:30][CH:29]=[C:28]2[NH:33][C:34]1[C:35](=[CH:39][CH:40]=[CH:41][CH:42]=1)[C:36]([OH:38])=[O:37].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[F:43][C:22]([F:21])([F:44])[C:23]1[CH:24]=[CH:25][CH:26]=[C:27]2[C:32]=1[N:31]=[CH:30][CH:29]=[C:28]2[NH:33][C:34]1[C:35](=[CH:39][CH:40]=[CH:41][CH:42]=1)[C:36]([O:38][CH2:3][C:4]([O:6][C:7]1([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH2:12][CH2:11][N:10]([CH3:13])[CH2:9][CH2:8]1)=[O:5])=[O:37]

参加物

6

反応物 4

HCID 11430Potassium CarbonateHCID 37541Floctafenic acidHCID 5360545SodiumHCID 20438865N-methyl-4-phenyl-4-piperidyl chloroacetate hydrochloride

生成物 1

HCID 16206495N-Methyl-4-phenyl-4-piperidyl N-(8-trifluoromethyl-4-quinolyl)anthraniloyloxyacetate

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A mixture of 1.52 g of N-methyl-4-phenyl-4-piperidyl chloroacetate hydrochloride, 1.77 g of the sodium salt of N-(8-trifluoromethyl-4-quinolyl)-anthranilic acid and 0.7 g of potassium carbonate in 10 ml of dimethylformamide was stirred for 48 hours at 20°-25° C. Upon completion of the reaction, the inorganic salts were filtered off. The solution was evaporated to dryness and treated with water, and the solid collected by filtration. This solid was then refluxed with hexane, filtered and recrystallized from hexane to provide the title compound. M.p. 144°-145° C., yield 1 g (35%).

後処理

  1. customUpon completion of the reaction
  2. filtrationthe inorganic salts were filtered off
  3. customThe solution was evaporated to dryness
  4. additiontreated with water
  5. filtrationthe solid collected by filtration
  6. temperatureThis solid was then refluxed with hexane
  7. filtrationfiltered
  8. customrecrystallized from hexane

出典と根拠

ORDレコード
ord-d371c46e99a743ea9f658f34ff924290
出典データセット
uspto-grants-1984_11
特許番号
US04482561

関連ノート

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