Hydrogen Bromide → 6-Chloro-7-hydroxy-3,4-dihydrocarbostyril
反応式
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[O:12]C)[NH:8][C:7](=[O:14])[CH2:6][CH2:5]2.Br>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[OH:12])[NH:8][C:7](=[O:14])[CH2:6][CH2:5]2参加物
3
実験手順
30 Grams of thus obtained 6-chloro-7-methoxy-3,4-dihydrocarbostyril was dispersed in 300 ml of 47% aqueous solution of hydrobromic acid and heated under refluxing condition for 4 hours. After the reaction mixture was cooled, the insoluble matters formed were obtained by filtration, washed with water, dried and recrystallized from methanol-chloroform. 25 Grams of 6-chloro-7-hydroxy-3,4-dihydrocarbostyril having the melting point of 264°-266° C. was obtained as in the form of colorless needle-like crystals.
後処理
- temperatureheated
- temperatureunder refluxing condition for 4 hours
- temperatureAfter the reaction mixture was cooled
- customthe insoluble matters formed
- customwere obtained by filtration
- washwashed with water
- customdried
- customrecrystallized from methanol-chloroform
出典と根拠
- ORDレコード
- ord-3d3f8b4c400d44f6a2821422cf88f71b
- 出典データセット
- uspto-grants-1984_11
- 特許番号
- US04482560
反応ノート
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