Methyl 2-(Trifluoromethyl)-3,3,3-trifluoropropionate → Methyl 3,3,3-trifluoropropanoate

A solution of 150 g (1.5 mol) of potassium acetate in 500 ml of water was added dropwise to a solution of 105 g (0.5 mol) of methyl 2-(trifluoromethyl)-3,3,3-trifluoropropionate as above produced in 250 ml of water and the mixture was refluxed for 5 hours. After separation of the oily layer, extraction was made from the water layer that was left with use of methylene chloride and the solution of extracts and separated oily layer were joined and dried. After methylene chloride was removed by evaporation under atmospheric pressure, purification was made by distillation to give methyl 3,3,3-trifluoropropionate (TFPE) (54.07 g, 76%). Its analysis gave the following data:

1. temperaturethe mixture was refluxed for 5 hours
2. customAfter separation of the oily layer, extraction
3. waitwas left with use of methylene chloride
4. customthe solution of extracts and separated oily layer
5. customdried
6. customAfter methylene chloride was removed by evaporation under atmospheric pressure, purification
7. distillationwas made by distillation

ORDレコード

ord-1282e9b3402f4933bea6537a1f0404ba

出典データセット

uspto-grants-1984_11

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US04482729