Thionyl Chloride → 3-(2-Chloroethyl)-1,4-dimethyl-2-piperazinone

HRID 1979813ノート

反応式

HRID 1979813 の反応式
S(Cl)([Cl:3])=O.O[CH2:6][CH2:7][CH:8]1[N:13]([CH3:14])[CH2:12][CH2:11][N:10]([CH3:15])[C:9]1=[O:16].C(=O)(O)[O-].[Na+]>C(Cl)Cl>[Cl:3][CH2:6][CH2:7][CH:8]1[N:13]([CH3:14])[CH2:12][CH2:11][N:10]([CH3:15])[C:9]1=[O:16]

参加物

5

反応物 3

HCID 24386Thionyl ChlorideHCID 516892Sodium BicarbonateHCID 133767393-(2-Hydroxyethyl)-1,4-dimethyl-2-piperazinone

生成物 1

HCID 133767413-(2-Chloroethyl)-1,4-dimethyl-2-piperazinone

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Thionyl chloride (1.5 mL) was added dropwise to an ice cooled methylene chloride (5 mL) solution of 3-(2-hydroxyethyl)-1,4-dimethyl-2-piperazinone (0.40 g, described in Example 1). The reaction mixture was stirred for 30 min and poured on an ice solution of 10% sodium bicarbonate. The mixture was extracted with methylene chloride, and the organic extract was dried and evaporated to give the title compound: IR (CHCl3) 1635 cm-1 ; and NMR (CDCl3) δ 2.35 (s, 3H) and 2.90 (s, 3H).

後処理

  1. extractionThe mixture was extracted with methylene chloride
  2. extractionthe organic extract
  3. customwas dried
  4. customevaporated

出典と根拠

ORDレコード
ord-99aeb12ef8364fc3beb4d1e190749932
出典データセット
uspto-grants-1984_11
特許番号
US04482714

反応ノート

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